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BMS-911543
Artikelnummer: LKT-B5000.1
BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3.
| Schlagworte: | BMS911543,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 1271022-90-2 |
| MW: | 432.52 D |
ab 188,00 €
BMS-911543
Artikelnummer: Cay21088-5
BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively. It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s =...
| Schlagworte: | N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridin... |
| Anwendung: | JAK2 inhibitor |
| CAS | 1271022-90-2 |
| MW: | 432.5 D |
ab 84,00 €
