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FGTI-2734
Artikelnummer: Cay37694-1
FGTI-2734 is a C-terminal mimetic of Ras and a dual inhibitor of farnesyltransferase (FTase) and geranylgeranyl transferase type I (GGTase I, IC50s = 250 and 520 nM, respectively). It inhibits prenylation of H-Ras and Rap1A in oncogenic H-Ras-transformed NIH3T3 cells (IC50s = 88.7 and 2,700 nM, respectively)....
| Schlagworte: | N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)-2-pyridinesulfonamide |
| Anwendung: | Ftase/GGTase I dual inhibitor |
| CAS | 1247018-19-4 |
| MW: | 510.6 D |
ab 42,00 €
FGTI-2734
Artikelnummer: TGM-T11282-100mg
Description: FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of...
| CAS | 1247018-19-4 |
| MW: | 510.63 D |
ab 45,00 €
