TIP60 (human, recombinant)

TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase. As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription. In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone gammaH2AX allows formation of the gammaH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of beta-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer's disease pathogenesis.Synonyms: cPLA(2) Interacting Protein, Esa1, Histone acetyltransferase KAT5, HIV-1 Tat Interacting Protein 60 kDa, Hs.6364, HTATIP, KAT5, PLIP. Purity: >50%. Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells. Amino Acids: 2-513 (Full length, Isoform 2). MW: 60.3 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 7.5, with 300 mM sodium chloride and 10% glycerol. UniProt Accession #: Q92993.