S100A11 Protein (His Tag)(Active) (recombinant mouse)

Activity: Immobilized Human ANXA2(Cat: PKSH032074) at 10µg/ml(100 µl/well) can bind Mouse S100A11-His. The ED50 of Mouse S100A11-His is 0.8µg/mL. Protein Construction: Recombinant Mouse S100-A11 is produced by our E.coli expression system and the target gene encoding Met1-Ile98 is expressed with a 6His tag at the N-terminus. Sequence: Met1-Ile98. Fusion tag: N-His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 12 kDa. Protein function: Protein S100-A11(S100A11) is a member of the S-100 family. S100A11 is widely expressed in multi pletissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferatin of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma. Protein function: Facilitates the differentiation and the cornification of keratinocytes. [The UniProt Consortium]