RIPK3, Recombinant, Human, aa1-518, His-Tag (Receptor-interacting Serine/threonine-Protein Kinase 3)

RIPK3, Recombinant, Human, aa1-518, His-Tag (Receptor-interacting Serine/threonine-Protein Kinase 3)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
375067.20 20 µg - -

3 - 19 Werktage*

416,00 €
375067.100 100 µg - -

3 - 19 Werktage*

637,00 €
 
Essential for necroptosis, a programmed cell death process in response to death-inducing... mehr
Produktinformationen "RIPK3, Recombinant, Human, aa1-518, His-Tag (Receptor-interacting Serine/threonine-Protein Kinase 3)"
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. Source: Recombinant protein corresponding to aa1-518 from human RIPK3, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~58.9kD, AA Sequence: MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: RIP3, RIPK3, RIP-3, EC=2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3
Hersteller: United States Biological
Hersteller-Nr: 375067

Eigenschaften

Konjugat: No
MW: 58,9
Format: Highly Purified

Handhabung & Sicherheit

Lagerung: °C
Versand: °C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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