Recombinant Rat CD81/TAPA Protein (RPES3936)

Recombinant Rat CD81/TAPA Protein (RPES3936)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3936.20 20 µg - - -

9 - 20 Werktage*

422,00 €
 
Recombinant Rat CD81/TAPA Protein from Assay Genie. Recombinant Rat CD81/TAPA Protein is a highly... mehr
Produktinformationen "Recombinant Rat CD81/TAPA Protein (RPES3936)"
Recombinant Rat CD81/TAPA Protein from Assay Genie. Recombinant Rat CD81/TAPA Protein is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen- induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation. Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption. May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels. Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung. [The UniProt Consortium]
Schlagworte: CD81, Cd81, Tapa1, CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1
Hersteller: Assay Genie
Hersteller-Nr: RPES3936

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Format: Highly Purified

Datenbank Information

UniProt ID : Q62745 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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