Recombinant Mouse KIRREL3/NEPH2 Protein (His Tag)(Active) (RPES2763)

Mouse KIRREL3/NEPH2 Recombinant Protein (RPES2763) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286). Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329). May be involved in the hematopoietic supportive capacity of stroma cells, the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856). [The UniProt Consortium]