Recombinant Human Platelet Receptor Gi24/VISTA/B7-H5/PD-1H (C-Fc)

Source: Human Cells. MW :45.3kD. Recombinant Human Platelet receptor Gi24 is produced by our Mammalian expression system and the target gene encoding Phe33-Ala194 is expressed with a Fc tag at the C-terminus. platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively. Protein function: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). [The UniProt Consortium]