Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active) (RPES4085)

Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active) (RPES4085)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4085.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active) from Assay Genie. Recombinant... mehr
Produktinformationen "Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active) (RPES4085)"
Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active) from Assay Genie. Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis, protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). [The UniProt Consortium]
Schlagworte: NgR, RTN4R, NOGOR, Nogo receptor, Nogo-66 receptor, Reticulon-4 receptor
Hersteller: Assay Genie
Hersteller-Nr: RPES4085

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K16659 | Passende Produkte
UniProt ID : Q9BZR6 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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