Recombinant Human Insulin-Like Growth Factor-Binding Protein 4/IGFBP-4 (C-6His)

Source: Human Cells. MW :27.01kD. Recombinant Human Insulin-Like Growth Factor-Binding Protein 4 is produced by our Mammalian expression system and the target gene encoding Asp22-Glu258 is expressed with a 6His tag at the C-terminus. IGFBP-4, whose full name is insulin-like growth factor-binding protein 4, is induced by forskolin and N6, O2'dibutyryl sdenosine 3', or 5'-cyclic monophosphate. It contains IGFBP N-terminal domain and thyroglobulin type-1 domain, and can bind IGF2. The IGF-binding proteins can prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. Protein function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [The UniProt Consortium]