Recombinant Human CEACAM5/CD66e/CEA (C-Fc)

Source: Human Cells. MW :98.9kD. Recombinant Human CEACAM5 is produced by our Mammalian expression system and the target gene encoding Lys35-Ala685 is expressed with a Fc tag at the C-terminus. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell-cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker. Protein function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. [The UniProt Consortium]