Recombinant Human AMPK (G1/B2/A1) Heterotrimer Protein

Recombinant Human AMPK (G1/B2/A1) Heterotrimer Protein
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH030313.20 20 µg - -

7 - 16 Werktage*

1.052,00 €
E-PKSH030313.50 50 µg - -

7 - 16 Werktage*

1.301,00 €
 
Protein function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy... mehr
Produktinformationen "Recombinant Human AMPK (G1/B2/A1) Heterotrimer Protein"
Protein function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. [The UniProt Consortium]
Hersteller: Elabscience
Hersteller-Nr: E-PKSH030313

Eigenschaften

Konjugat: No
Ursprungsart: Human
Format: Solution

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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