Ras-related protein Rab-14/RAB14 protein (His tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human RAB14 protein (P61106) (Ala 2-Cys 215) was expressed with a C-His and N-His. Sequence: Ala 2-Cys 215. Fusion tag: N-His & C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 31 kDa. Protein function: RAB14 is a member of Rab GTPases that regulate the roles and identity of endosomes. Rab14 collaborates with FAM116 in regulating proteolytic cleavage of N-cadherin, and modulation of cell-cell adhesion and cell motility. Rab14 mediates the endocytic trans Protein function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. [The UniProt Consortium]