PPM1A protein (His tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human PPM1A protein (P35813) (Gly 2-Trp 382) was expressed with a N-His. Sequence: Gly2-Trp382. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 45 kDa. Protein function: Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinas Protein function: Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. [The UniProt Consortium]