PAI-1/ SerpinE1 protein (His tag), recombinant rat

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat PAI-1/ SerpinE1 protein (P20961) (Ser 24-Pro 402) was expressed with N-His tag. Sequence: Ser 24-Pro 402. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 42 kDa. Protein function: Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may Protein function: Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. [The UniProt Consortium]