NCoR2, Recombinant, Human (SMRT, Nuclear Receptor Co-Repressor)

NcoR2 (nuclear receptor co-repressor) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. The interaction of HDAC3 with the deacetylase activation domain (DAD) of NCOR2/SMRT is required for activation of the otherwise inert deacetylase. Recombinant human NCoR2 contains aa395-489 with an N-terminal GST tag (GenBank Accession No. NM_006312). Applications: Useful for the study of enzyme kinetics, screening inhibitors and selectivity profiling. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.