IL-1 Receptor Type I:Fc, Recombinant, Human (RI, Interleukin-1 Receptor Type I, CD121a, Interleukin-

IL-1RI is the receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappaB. Signaling involves formation of a ternary complex containing IL1RAP, leading the activation of TOLLIP, MYD88, and IRAK1 or IRAK2. Biological Activity: Blocks IL-1 beta activity. Sequence: Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4°C, Long-term Storage: -20°C, Stable for at least 6 months after receipt when stored at -20°C.