GRB2, Recombinant, Human (Growth factor receptor-bound protein 2 isoform 1, ASH, EGFRBP-GRB2, GRB3-3

Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed. It binds the epidermal growth factor receptor. It is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. Recombinant protein corresponding to human GRB2 protein, fused to His-tag at N-terminus, expressed in E. coli (NP_002077). , Molecular Weight: 27kD (237aa), AA Sequence: MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD, GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG, DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.