Glypican-1/GPC1 protein (His tag), recombinant human

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Human GPC1 protein (P35052) (Asp24-Ser530) was expressed with a C-His. Sequence: Asp24-Ser530. Fusion tag: C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 58 kDa. Protein function: The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 aa signal sequence, a 507 aa mature Protein function: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. [The UniProt Consortium]