Galectin-3, Human

Sequence: ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYPGAPGAYP GAPAPGVYPG AYPSSGQPSA TGAYPATGPY GAPAGPLIVP YNLPLPGGVV PRMLITILGT VKPNANRIAL DFQRGNDVAF HFNPRFNENN RRVIVCNTKL NNWGREERQS VFPFESGKPF KIQVLVEPDH FKVAVNDAHL LQYNHRVKKL NEISKLGISG DIDLTSASYT with polyhistidine tag at the N-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. [The UniProt Consortium]