FADD protein-HIS Epitope

Recombinant full-length human FADD was expressed in E. coli cells using an N-Terminal his epitope. The purity was determined to be >95% by densitometry. Protein function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. [The UniProt Consortium]