Contactin-6 (human):Fc (human, rec.)

Human contactin-6 (amino acids 1-999) is fused at the C-terminus to the Fc portion of human IgG. Induces Hes-1 in 3T3L-1 cells. Liquid. 0.2µm-filtered solution in PBS. Contactin-6 is a member of the contactins, which mediate cell surface interactions during nervous system development. Contactin-6 has a key role in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum. It is involved in oligodendrocytes generation by acting as a ligand of Notch1. It is also involved in motor coordination.