Citrullinated Histone H2A Type 1 (human, recombinant)

Citrullinated histone H2A type 1 is a citrullinated form of histone H2A, a core histone and a component of the nucleosome that wraps and condenses DNA. Histone H2A is subject to citrullination by protein arginine deiminase 4 (PAD4) at the arginine residue at position 3. Autoantibodies to histone H2A and citrullinated histone H2A are increased in the plasma of rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies (CCP+) but not in the plasma of CCP- patients. Cayman's Citrullinated Histone H2A Type 1 (human, recombinant) protein can be used for Western blot and ELISA applications.Synonyms: H2A Clustered Histone 11, H2A Histone Family, Member P, H2A Type 1, H2A.1, H2AC11, H2AFP, HIST1H2AG, Histone H2A/ptl. Purity: >90% estimated by SDS-PAGE. Protein Identity Confirmed by Mass Spec: Yes. Source: Recombinant human histone H2A type 1 expressed in E. coli, citrullinated with recombinant human PAD4. Amino Acids: 2-130 (full length). MW: 13.96 kDa. Formulation: (Request formulation change), Water. UniProt Accession #: P0C0S8.