CHMP3 PrEST Antigen

CHMP3 PrEST Antigen
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-APrEST94386.100 100 µl - -

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186,00 €
 
Protein function: Probable core component of the endosomal sorting required for transport complex... mehr
Produktinformationen "CHMP3 PrEST Antigen"
Protein function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
Schlagworte: CHMP3, hVps24, CGI149, CGI-149, Chromatin-modifying protein 3, Charged multivesicular body protein 3, Neuroendocrine differentiation factor, Vacuolar protein sorting-associated protein 24
Hersteller: Atlas Antibodies
Hersteller-Nr: APrEST94386

Eigenschaften

Anwendung: Control antigen
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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