Calreticulin (human, rec.) (His)

Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag. Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Calreticulin is involved in regulation of intracellular Ca2 homoeostasis and ER Ca2 capacity. It constitutes together with calnexin and ERp57 the 'calreticulin/calnexin cycle' that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule.