B7-H4/VTCN1 Protein (Fc Tag), recombinant rhesus macaque

Activity: Testing in progress Protein Construction: Recombinant Rhesus macaque B7-H4 is produced by our Mammalian expression system and the target gene encoding Phe29-Ala258 is expressed with a Fc tag at the C-terminus. Sequence: Phe29-Ala258. Fusion tag: C-hFc Endotoxin: <1.0 EU per µg of the protein as determined by the LAL method. Apparent Molecular Mass: 70-100 kDa. Protein function: B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.