Angiopoietin-1/ANG1 protein (His tag), recombinant rat

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat ANG1 protein (O35460) (Asn304-Ala450) was expressed with a N-His . Sequence: Asn304-Ala450. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 18 kDa. Protein function: Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 i Protein function: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. [The UniProt Consortium]