PtdIns-(4,5)-P2-biotin (sodium salt)

The PtdIns phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(4,5)-P2-biotin is an affinity probe which allows the PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to serve as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.Formal Name: 1-((1-octanoyl-N'-biotinoyl-1,6-diaminohexane-2R-octanoyl)phosphatidyl)inositol-4,5-bisphosphate, trisodium salt. Synonyms: DOPI-4,5-P2-biotin, Phosphatidylinositol-4,5-diphosphate C-8-biotin, PI(4,5)P2-biotin, PIP2[4',5']-biotin. Molecular Formula: C35H61N3O21P3S . 3Na. Formula Weight: 1053.8. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](O)[C@H](O)[C@@H]1OP([O-])(OC[C@H](COC(CCCCCCCNC(CCCC[C@H]2SC[C@@](N3[H])([H])[C@]2([H])N([H])C3=O)=O)=O)OC(CCCCCCC)=O)=O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C35H64N3O21P3S.3Na/c1-2-3-4-6-10-17-27(41)56-22(20-55-62(52,53)59-32-29(42)30(43)33(57-60(46,47)48)34(31(32)44)58-61(49,50)51)19-54-26(40)16-9-7-5-8-13-18-36-25(39)15-12-11-14-24-28-23(21-63-24)37-35(45)38-28,,,/h22-24,28-34,42-44H,2-21H2,1H. InChi Key: USLRCVJGAGJDIV-WFWFDGKXSA-K.