Prostaglandin E2-1-glyceryl ester

2-Arachidonoyl glycerol (2-AG, Cay-62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.Formal Name: 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, 1-glyceryl ester. CAS Number: 37497-47-5. Synonyms: PGE2-1-glyceryl ester. Molecular Formula: C23H38O7. Formula Weight: 426.6. Purity: >98% (as a 85:15 mixture of the 1- and 2-glyceryl esters). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 100 µg/ml. SMILES: O=C1[C@H](C/C=C\CCCC(OCC(O)CO)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C23H38O7/c1-2-3-6-9-17(25)12-13-20-19(21(27)14-22(20)28)10-7-4-5-8-11-23(29)30-16-18(26)15-24/h4,7,12-13,17-20,22,24-26,28H,2-3,5-6,8-11,14-16H2,1H3/b7-4-,13-12+/t17-,18?,19+,20+,22+/m0/s1. InChi Key: RJXVYMMSQBYEHN-LVXZDWGESA-N.