Prostaglandin D2-1-glyceryl ester

2-Arachidonoyl glycerol (2-AG, Cay-62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with COX-2 and specific prostaglandin H2 (PGH2, Cay-17020) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. In RAW 264.7 cells, PGD2-2-glyceryl ester is the main COX metabolite. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 mixture of the 1- and 2-glyceryl esters in typical aqueous media. While the stability and metabolism of these PG products have been investigated, little is known about their intrinsic biological activity.Formal Name: 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid, 1-glyceryl ester. CAS Number: 309260-52-4. Synonyms: PGD2-1-glyceryl ester. Molecular Formula: C23H38O7. Formula Weight: 426.6. Purity: >95% (as a 9:1 mixture of the 1- and 2-glyceryl esters). Formulation: (Request formulation change), A solution in acetonitrile. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): .1 mg/ml. SMILES: CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)OCC(O)CO. InChi Code: InChI=1S/C23H38O7/c1-2-3-6-9-17(25)12-13-20-19(21(27)14-22(20)28)10-7-4-5-8-11-23(29)30-16-18(26)15-24/h4,7,12-13,17-21,24-27H,2-3,5-6,8-11,14-16H2,1H3/b7-4-,13-12+/t17-,18?,19+,20+,21-/m0/s1. InChi Key: AWSHXGOINMVSGP-LJAYCTNTSA-N.