LY83583

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 µM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 µM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 µM.Formal Name: 6-(phenylamino)-5,8-quinolinedione. CAS Number: 91300-60-6. Molecular Formula: C15H10N2O2. Formula Weight: 250.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: 25 mg/ml DMSO:PBS pH 7.2: can dilute to 1:175 (>140 µg/m, acidic PBS: <100 µg/ml, basic PBS: <100 µg/ml, DMF: >25 mg/ml, DMSO: >25 mg/ml, Ethanol: >3.8 mg/ml, PBS pH 7.2: <100 µg/ml. SMILES: O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12. InChi Code: InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H. InChi Key: GXIJYWUWLNHKNW-UHFFFAOYSA-N.