LPS from E. coli O55:B5 (S-form) TLRpure Sterile Solution

LPS from E. coli O55:B5 (S-form) TLRpure Sterile Solution
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
IAX-100-013-C500 500 µg -

3 - 9 Werktage

180,00 €
IAX-100-013-M001 1 mg - -

3 - 9 Werktage

206,00 €
 
Optimal concentration is dependent upon cell type, species, desired activation and analysis:... mehr
Produktinformationen "LPS from E. coli O55:B5 (S-form) TLRpure Sterile Solution"
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). Re-form LPS and lipid A, but not S-form LPS, are capable of inducing TNF-alpha responses also in the absence of CD14. LPS, synthesized by most wild-type (WT) Gram-negative bacteria (S-form LPS), consists of three regions, the O-polysaccharide chain, which is made up of repeating oligosaccharide units, the core oligosaccharide and the lipid A, which harbors the endotoxic activity of the entire molecule. R-form LPS synthesized by the so-called rough (R) mutants of Gram-negative bacteria lacks the O-specific chain. Furthermore, the core-oligosaccharide may be present in different degrees of completion, depending on the class (Ra to Re) to which the mutant belongs. LPS are amphipathic molecules whose hydrophobicity decreases with increasing length of the sugar part. Based upon these differences, S- and R-form LPS show marked differences in the kinetics of their blood clearance and cellular uptake as well as in the ability to induce oxidative burst in human granulocytes and to activate the host complement system.
Schlagworte: Lipopolysaccharide (LPS) from E. coli O55:B5, S-type (smooth/wild-type) LPS
Hersteller: Innaxon
Hersteller-Nr: IAX-100-013-M001

Eigenschaften

Anwendung: TLR4 activator
Reinheit: >99.9%
Format: Purified

Datenbank Information

KEGG ID : K10160 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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