gamma-Linolenic Acid ethyl ester

gamma-Linolenic acid (GLA) is an omega-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction. GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets.Formal Name: 6Z,9Z,12Z-octadecatrienoic acid, ethyl ester. CAS Number: 31450-14-3. Synonyms: GLA ethyl ester. Molecular Formula: C20H34O2. Formula Weight: 306.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 500 mg/ml. SMILES: CCCCC/C=C\C/C=C\C/C=C\CCCCC(OCC)=O. InChi Code: InChI=1S/C20H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-4-2/h8-9,11-12,14-15H,3-7,10,13,16-19H2,1-2H3/b9-8-,12-11-,15-14-. InChi Key: MJLYTDAIYLGSRZ-ORZIMQNZSA-N.