ent-8-iso-15(S)-Prostaglandin F2alpha

Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2alpha (ent-8-iso-15(S)-PGF2alpha) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2alpha in a whole blood platelet aggregation inhibition assay.Formal Name: 9beta,11beta,15S-trihydroxy-(12beta)-prosta-5Z,13E-dien-1-oic acid. CAS Number: 214748-66-0. Synonyms: ent-15-epi-F2t-Isoprostane, ent-8-iso-15-epi-PGF2alpha. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A solution in acetonitrile. Solubility: 10 mM Na2CO3: >6.5 mg/ml, DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >10 mg/ml. SMILES: O[C@H]1[C@H](C/C=C\CCCC(O)=O)[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17-,18+,19-/m0/s1. InChi Key: PXGPLTODNUVGFL-XNTKLVSTSA-N.