Delta12-Prostaglandin J2

Delta12-Prostaglandin J2 (Delta12-PGJ2) is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml. Delta12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARgamma ligand.Formal Name: 15S-hydroxy-11-oxo-prosta-5Z,9,12E-trien-1-oic acid. CAS Number: 87893-54-7. Synonyms: Delta12-PGJ2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >100 mg/ml, DMSO: >50 mg/ml, Ethanol: >75 mg/ml, PBS (pH 7.2): >2.7 mg/ml. lambdamax: 244 nm. SMILES: CCCCC[C@H](O)C/C=C([C@@H](C/C=C\CCCC(O)=O)C=C1)/C1=O. InChi Code: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1. InChi Key: TUXFWOHFPFBNEJ-GJGHEGAFSA-N.