CAY10580

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). CAY10580 stimulates cAMP formation in excised mouse ovaries.Formal Name: 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid. CAS Number: 64054-40-6. Molecular Formula: C19H35NO4. Formula Weight: 341.5. Purity: >96%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 2.5 mg/ml. SMILES: CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O. InChi Code: InChI=1S/C19H35NO4/c1-2-3-6-9-17(21)13-11-16-12-14-18(22)20(16)15-8-5-4-7-10-19(23)24/h16-17,21H,2-15H2,1H3,(H,23,24). InChi Key: CBWGHEDGUILASE-UHFFFAOYSA-N.