Arachidonic Acid-biotin

Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signalling and inflammation. Arachidonic acid-biotin was designed to allow arachidonic acid to be detected in complexes with protein binding partners such as fatty acid binding proteins (FABPs). It is thus a tool to be used in the general elucidation of the signaling and transport of free arachidonic acid. Formal Name: 5Z,8Z,11Z,14Z-eicosatetraenoyl-N'-biotinoyl-1,5-diaminopentane. CAS Number: 1217901-28-4. Molecular Formula: C35H58N4O3S. Formula Weight: 614.9. Purity: >95%. Formulation: A solution in ethanol. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): .15 mg/ml. SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N(CCCCCNC(CCCC[C@@H]1SC[C@@](N2[H])([H])[C@]1([H])N([H])C2=O)=O)[H])=O. InChi Code: InChI=1S/C35H58N4O3S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-25-32(40)36-27-22-18-23-28-37-33(41)26-21-20-24-31-34-30(29-43-31)38-35(42)39-34/h6-7,9-10,12-13,15-16,30-31,34H,2-5,8,11,14,17-29H2,1H3,(H,36,40)(H,37,41)(H2,38,39,42)/b7-6-,10-9-,13. InChi Key: RPYSWRMECJXHSJ-QYXQEGSISA-N.