8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha

8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha (8-iso-13,14-dihydro-15-keto PGF2alpha) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2alpha), in rabbits, monkeys and humans. 8-iso PGF2alpha is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by beta-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2alpha was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2alpha weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.Formal Name: (8beta)-9alpha,11alpha-dihydroxy-15-oxo-prost-5Z-en-1-oic acid. CAS Number: 191919-02-5. Synonyms: 8-iso-13,14-dihydro-15-keto PGF2alpha. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml, DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >10 mg/ml. SMILES: O[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17+,18-,19+/m0/s1. InChi Key: VKTIONYPMSCHQI-JPRPWBOBSA-N.