8,12-iso-iPF2alpha-VI-d11

8,12-iso-isoprostane F2alpha-VI-d11 (8,12-iso-iPF2alpha-VI-d11) contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8,12-iso-iPF2alpha-VI by GC- or LC-mass spectrometry. The relative abundance of deuterium atoms incorporated into each molecule has not been determined. Cayman certifies that less that 1% of the product has no deuterium incorporation (enzymatic, non-cyclooxygenase prostanoid products of peroxidative damage to membrane lipids. Among the many isoprostane isomers, 8,12-iso-iPF2alpha-VI has been demonstrated to be one of the predominant isomers formed and is also present in urine as one of the major isoprostane products. 8,12-iso-iPF2alpha-VI-d11 is a deuterated internal standard for use in isoprostane quantitation by mass spec modalities. The compound is diastereomeric at C-5, but is otherwise an optically active, single enantiomer.Formal Name: (12alpha)-5,9alpha,11alpha-trihydroxy-prosta-6E,14Z-dien-1-oic-16,16,17,17,18,18,19,19,20,20,20-d11 acid. CAS Number: 1616977-85-5. Synonyms: 8,12-iso-Isoprostane-F2alpha-VI-d11, 12-iso-5,6E,14Z-PGF2alpha-d11, 12-iso-5,6E,14Z-Prostaglandin F2alpha-d11. Molecular Formula: C20H23D11O5. Formula Weight: 365.6. Purity: >99% deuterated forms (d1-d11). Formulation: (Request formulation change), A solution in acetonitrile. Solubility: DMF: >100mg/ml (PGF2 alpha), DMSO: >100mg/ml (PGF2 alpha), Ethanol: >100mg/ml (PGF2 alpha), PBS pH 7.2: 3 mg/ml (PGF2 alpha). SMILES: OC(CCCC(O)=O)/C=C/[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@H](O)C[C@@H]1O. InChi Code: InChI=1S/C20H34O5/c1-2-3-4-5-6-7-10-16-17(19(23)14-18(16)22)13-12-15(21)9-8-11-20(24)25/h6-7,12-13,15-19,21-23H,2-5,8-11,14H2,1H3,(H,24,25)/b7-6-,13-12+/t15?,16-,17+,18+,19-/m0/s1/i1D3,2D2,3D2,4D2,5D2. InChi Key: RZCPXIZGLPAGEV-JVUJZTPFSA-N.