FTAC8

FTAC8 is a detergent that can be used to stabilize membrane proteins. It has a critical micelle concentration (CMC) of 0.02 mM. It has been used in the cell-free synthesis and purification of histidine-tagged MscL, a mechanosensitive membrane channel, as well as in the insertion of MscL into liposomes. FTAC8 has also been used in the synthesis of MscL in vitro and preserves its activity.Formal Name: N1,N3,N5,N7,N9,N11,N13,N15,N17,N19,N21,N23-dodecakis(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-24-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)thio)tetracosane-1,3,5,7,9,11,13,15,17,19,21,23-dodecacarboxamide. Synonyms: C8F-TAC. Formulation: (Request formulation change), A powder. SMILES: [H]C(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CC(C(NC(CO)(CO)CO)=O)CSCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F. InChi Code: InChI=1S/C94H161F17N12O48S/c95-87(96,88(97,98)89(99,100)90(101,102)91(103,104)92(105,106)93(107,108)94(109,110)111)3-4-172-15-62(74(171)123-86(49-157,50-158)51-159)14-61(73(170)122-85(46-154,47-155)48-156)13-60(72(169)121-84(43-151,44-152)45-153)12-59(71(168)120-83(40-148,41-149)42-150)11-58(70(167)119-82(37-145,38-146)39-147)10-57(69(166)118-81(34-142,35-143)36-144)9-56(68(165)117-80(31-139,32-140)33-141)8-55(67(164)116-79(28-136,29-137)30-138)7-54(66(163)115-78(25-133,26-134)27-135)6-53(65(162)114-77(22-130,23-131)24-132)5-52(64(161)113-76(19-127,20-128)21-129)1-2-63(160)112-75(16-124,17-125)18-126/h52-62,124-159H,1-51H2,(H,112,160)(H,113,161)(H,114,162)(H,115,163)(H,116,164)(H,117,165)(H,118,166)(H,119,167)(H,120,168)(H,121,169)(H,122,170)(H,123,171). InChi Key: DTZHFSXYJVWWGV-UHFFFAOYSA-N.