Zidovudine

Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI). It is phosphorylated intracellularly to its active form zidovudine-5'-triphosphate by the successive actions of thymidine kinase, thymidylate kinase, and nucleoside diphosphate kinase. Zidovudine (0.01, 0.1, and 1 µM) reduces HIV-1 p24 antigen levels in the culture supernatant of HIV-1-infected isolated human peripheral blood monocytes. Formulations containing zidovudine have been used in the treatment of HIV infections.Formal Name: 3'-azido-3'-deoxy-thymidine. CAS Number: 30516-87-1. Synonyms: Azidothymidine, AZT, NSC 602670, ZDV. Molecular Formula: C10H13N5O4. Formula Weight: 267.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 209, 266 nm. SMILES: CC1=CN([C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])C2)C(NC1=O)=O. InChi Code: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6?,7-,8-/m1/s1. InChi Key: HBOMLICNUCNMMY-SPDVFEMOSA-N.