viFSP1

viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1, IC50s = 34 and 83 nM for the human and mouse enzymes, respectively). It induces ferroptosis in glutathione peroxidase 4 (Gpx4) knockout Pfa1 mouse embryonic fibroblasts expressing human or mouse FSP1, an effect that can be reversed by the ferroptosis inhibitor liproxstatin-1 (Cay-17730).Formal Name: 5-amino-1-(2,4-dimethoxyphenyl)-1,2-dihydro-4-(4-methyl-2-thiazolyl)-3H-pyrrol-3-one. CAS Number: 951945-67-8. Synonyms: Versatile Inhibitor of Ferroptosis Suppressor Protein 1, Versatile Inhibitor of FSP1. Molecular Formula: C16H17N3O3S. Formula Weight: 331.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Chloroform: Soluble. SMILES: COC1=CC=C(N2C(N)=C(C3=NC(C)=CS3)C(C2)=O)C(OC)=C1. InChi Code: InChI=1S/C16H17N3O3S/c1-9-8-23-16(18-9)14-12(20)7-19(15(14)17)11-5-4-10(21-2)6-13(11)22-3/h4-6,8H,7,17H2,1-3H3. InChi Key: OUJMVDXLUWMMEC-UHFFFAOYSA-N.