Trimidox

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.Formal Name: N,3,4,5-tetrahydroxy-benzenecarboximidamide. CAS Number: 95933-74-7. Synonyms: VF 233. Molecular Formula: C7H8N2O4. Formula Weight: 184.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 214, 261 nm. SMILES: OC1=C(O)C(O)=CC(C(NO)=N)=C1. InChi Code: InChI=1S/C7H8N2O4/c8-7(9-13)3-1-4(10)6(12)5(11)2-3/h1-2,10-13H,(H2,8,9). InChi Key: MSLJYSGFUMYUDX-UHFFFAOYSA-N.