Triacsin C

Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 µM in Raji cells). It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters. It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability. Triacsin C can inhibit pancreatic beta-cell function by suppressing the mobilization of intracellular calcium.Formal Name: 2E,4E,7E-undecatrienal, nitrosohydrazone. CAS Number: 76896-80-5. Synonyms: FR 900190, WS 1228A. Molecular Formula: C11H17N3O. Formula Weight: 207.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, Methanol: 5 mg/ml. lambdamax: 301 nm. SMILES: CCC/C=C/C/C=C/C=C/C=N/NN=O. InChi Code: InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+. InChi Key: NKTGCVUIESDXPU-YLEPRARLSA-N. Origin: Bacterium/Streptomyces aureofaciens.