trans-Resveratrol-d4

trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Cay-70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 µM, respectively), but not COX-2 (EC50s = >100 µM and 85 µM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014, EC50 = 27 µM). trans-Resveratrol (1-25 µmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 µM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCalpha, aromatase/CYP19, and DNA polymerases alpha and delta (IC50s = 37, 50, 20, in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.Formal Name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol-2,3,5,6-d4. CAS Number: 1089051-56-8. Synonyms: (E)-Resveratrol-d4. Molecular Formula: C14H8D4O3. Formula Weight: 232.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >100 mg/ml, DMSO: >50mg/ml, Ethanol: >50mg/ml, PBS (pH 7.2): <100 µg/ml. lambdamax: 307, 320 nm. SMILES: Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1. InChi Code: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+/i3D,4D,5D,6D. InChi Key: LUKBXSAWLPMMSZ-RRQWMZAJSA-N.