Tetrahydrouridine

Tetrahydrouridine is an inhibitor of cytidine deaminase (Kis = 54 and 240 nM for the human and E. coli enzymes, respectively). In vivo, tetrahydrouridine inhibits the metabolism of decitabine (Cay-11166) and enhances decitabine-induced inhibition of tumor growth in a B16 murine melanoma model.Formal Name: 3,4,5,6-tetrahydro-uridine. CAS Number: 18771-50-1. Synonyms: NSC 112907, THU. Molecular Formula: C9H16N2O6. Formula Weight: 248.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/mL, DMSO: 10 mg/ml, PBS (pH 7.2): 5 mg/mL. SMILES: O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(O)CC2)=O. InChi Code: InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1. InChi Key: UCKYOOZPSJFJIZ-XVKVHKPRSA-N.