RR6

RR6 is an inhibitor of the pantetheinase vanin-1 (IC50 = 0.54 µM for the recombinant human enzyme) and is a derivative of the CoA precursor D-pantothenic acid (Cay-17288). It is selective for vanin-1 over biotinidase, cathepsin B, cathepsin L, and papain (IC50s = >200 µM for all). RR6 is active against P. falciparum (IC50 = 14.5 µM). It reduces plasma levels of cholesterol and increases plasma levels of free fatty acids in fasted rats when administered in the drinking water at 3 mg/ml. RR6 decreases neointima formation and macrophage infiltration in aortic allografts in a rat model of transplant vasculopathy.Formal Name: 2R-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)-butanamide. CAS Number: 1351758-37-6. Molecular Formula: C16H23NO4. Formula Weight: 293.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: Soluble, Methanol: Soluble. SMILES: O=C(CC1=CC=CC=C1)CCNC([C@@H](C(C)(CO)C)O)=O. InChi Code: InChI=1S/C16H23NO4/c1-16(2,11-18)14(20)15(21)17-9-8-13(19)10-12-6-4-3-5-7-12/h3-7,14,18,20H,8-11H2,1-2H3,(H,17,21)/t14-/m0/s1. InChi Key: PTVUGLNOPRZQEY-AWEZNQCLSA-N.