PRGL493

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone (Cay-15876) induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.Formal Name: N-(4-(3-(5-methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-yl)acetamide. CAS Number: 2479378-45-3. Molecular Formula: C25H21N7O2. Formula Weight: 451.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 1 mg/ml. lambdamax: 305 nm. SMILES: CC(NC1=NC2=NC3=C(C=CC=C3)N2C(C4=CN(C5=CC=CC=C5)N=C4C6=CC=C(C)O6)N1)=O. InChi Code: InChI=1S/C25H21N7O2/c1-15-12-13-21(34-15)22-18(14-31(30-22)17-8-4-3-5-9-17)23-28-24(26-16(2)33)29-25-27-19-10-6-7-11-20(19)32(23)25/h3-14,23H,1-2H3,(H2,26,27,28,29,33). InChi Key: QNWGOBIYAPLFMK-UHFFFAOYSA-N.