PPTN (hydrochloride)

PPTN is an antagonist of the purinergic P2Y14 receptor. It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1beta and chemokine (C-C motif) ligand 2 (CCL2) secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat satellite glial cells (SGCs). Trigeminal administration of PPTN (5 and 10 µM) reduces mechanical hyperalgesia induced by complete Freund's adjuvant (CFA) in rats.Formal Name: 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid, monohydrochloride. CAS Number: 1992047-65-0. Molecular Formula: C29H24F3NO2 . HCl. Formula Weight: 512.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 268 nm. SMILES: O=C(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5CCNCC5)C=C4)=C1)O.Cl. InChi Code: InChI=1S/C29H24F3NO2.ClH/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20,/h1-10,15-17,20,33H,11-14H2,(H,34,35),1H. InChi Key: FKMVYPCBLWYNAV-UHFFFAOYSA-N.