PPM-18

PPM-18 is a naphthoquinone compound that inhibits NF-kappaB activation in vitro and in vivo (IC50 = 5 µM). Through this action, it inhibits the expression of inducible nitric oxide synthase (iNOS) in macrophages treated with lipopolysaccharide and suppresses inflammation and sepsis.Formal Name: N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-benzamide. CAS Number: 65240-86-0. Synonyms: NSC 73233. Molecular Formula: C17H11NO3. Formula Weight: 277.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml. lambdamax: 257, 282 nm. SMILES: O=C(NC1=CC(=O)c2ccccc2C1=O)c1ccccc1. InChi Code: InChI=1S/C17H11NO3/c19-15-10-14(16(20)13-9-5-4-8-12(13)15)18-17(21)11-6-2-1-3-7-11/h1-10H,(H,18,21). InChi Key: BIVQBWSIGJFXLF-UHFFFAOYSA-N.